Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-08-25
2008-09-02
Weber, Jon P (Department: 1656)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S011400, C514S013800, C514S018700, C530S317000
Reexamination Certificate
active
07419954
ABSTRACT:
The present invention provides a cyclic peptide comprising the structure:wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2—X(n)-Z-X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of to an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.
REFERENCES:
patent: 5616320 (1997-04-01), Argoudelis et al.
patent: 6953833 (2005-10-01), Muir et al.
Wright et al., Transient interference withStaphylococcal quorumsensing blocks abscess formation, Proc. Natl. Acad Sci., 102:1691-1696 (2005).
Beavis Ronald
Ji Guangyong
Mayville Patricia
Muir Tom W.
Novick Richard P.
Klauber & Jackson LLP
Mitra Rita
The Rockefeller University
Weber Jon P
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