Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1997-09-26
1999-12-21
Degen, Nancy
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
435 691, 43525233, 4353201, 514 44, 536 237, A61K 39085, A61K 3170, C07H 2104, C12P 2102
Patent
active
060045566
ABSTRACT:
rsbU-1 polypeptides and DNA (RNA) encoding such rsbU-1 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such rsbU-1 for the treatment of infection, particularly bacterial infections. Antagonists against such rsbU-1 and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of rsbU-1 nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding SigB operon and for detecting the polypeptide in a host.
REFERENCES:
Wu et al. (1996) Sigma-B, a putative operon encoding alternate sigma factor of Staphylococcus aureus RNA polymerase: molecular cloning and DNA sequencing. J. Bacteriol. 178:6036-6042, Oct. 17, 1996.
Orkin et al. (1995) Report and recommendations of the panel to assess the NIH investment in research on gene therapy, Dec. 1995.
Voelker et al. (1996) The yeast two-hybrid system detects interactions between Bacillus subtilis sigma B regulators. J. Bacteriol. 178:7020-7023, Dec. 1996.
Sigma Chemical Company catalogue (1993) p. 1761, 1993.
Kullik, et al., "The Alternative Sigma Factor .smallcircle..sup.B in Staphylococcus aureus: Regulation of the sigB Operon in Response to Growth Phase and Heat Shock", Arch Microbiol, vol. 167, pp. 151-159, (1997).
Benjamini, et al., Immunology--A Short Course, Third Edition, Published by Wiley-Liss, (1996).
Davis, et al., "Direct Gene Transfer in Skeletal Muscle: Plasmid DNA-based Immunization Against the Hepatitis B Virus Surface Antigen", Vaccine, vol. 12, No. 16, pp. 1503-1509, (1994).
Fosberry Andrew P
Lawlor Elizabeth J
Nicholas Richard O
Degen Nancy
Deibert Thomas S.
Gimmi Edward R.
King William T.
Schwartzman Robert
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