Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Reexamination Certificate
2007-05-29
2007-05-29
Devi, S. (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
C424S190100, C424S234100, C424S184100, C424S243100, C424S832000, C530S350000, C530S825000, C435S320100, C435S069300, C536S023700
Reexamination Certificate
active
10203536
ABSTRACT:
The present invention relates to a method of producing recombinant modified Staphylococcal toxin having improved stability, comprising the steps of preparing a modified toxin in which a specific amino acid sequence is substituted and a vector for expressing the modified toxin, and culturingE. colitransformed with the vector, and a use thereof for the vaccine.
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Gregory A. Bohach et al., “Nucleotide sequence of the staphylococcal enterotoxin C1 gene and relatedness to other pyrogenic toxins”, Molecular General Genetics, (1987).
Terence N. Turner et al., “Residues 20, 22 and 26 Determine the Subtype Specificities of Staphylococcal Enterotoxins C1 and C2”, Infection and Immunity, Feb. 1992, vol. 60, No. 2, pp. 694-697.
C.J. Hovde et al., Molecular Biology, vol. 13, No. 4, pp. 897-909, No. 4 (1994).
KK. Pulling et al., Abstracts of the 91stGeneral Meeting of the American Society for Microbiology, vol. 9, pp. 71 (1991).
G.A. Bohach et al., Natural Toxins 2, pp. 131-154, pp. 143-147 (1996).
W.A. Ferens et al., Infect-Immun-, vol. 66, pp. 573-580, vol. 66, No. 2 (1998).
Chang Byoung-Sun
Han Kyu-Boem
Lee Hong-Kyun
Lee Yong-Jun
Park Yong-Ho
Birch & Stewart Kolasch & Birch, LLP
Devi S.
LG Chem-Investment Ltd.
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