Stannylated 3-quinuclidinyl benzilates and methods of preparing

Details Stannylated 3-quinuclidinyl benzilates and methods of preparing Stannylated 3-quinuclidinyl benzilates and methods of preparing

1994-04-19

1996-10-29

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

546137, 514305, A61K 5104, C07D45302, A01N 4390

Patent

active

055694470

ABSTRACT:
The present invention provides stannylated 3-quinuclidinyl benzilate compounds and a method of synthesizing *AQNB by iodinating such stannylated 3-quinuclidinyl benzilate compounds. The iodination of these stannylated 3-quinuclidinyl benzilates proceeds in as little as five minutes; thus, the stannylated 3-quinuclidinyl benzilates may be converted to *AQNB in situ for immediate use. Using this method, radiolabelling yields as high as 80% have been observed. The present invention also is directed towards a method of synthesis of the stannylated 3-quinuclidinyl benzilate compounds. The method comprises providing a 4'-halo-3-quinuclidinyl benzilate and reacting the 4'-halo-3-quinuclidinyl benzilate with a compound having the formula (SnR.sub.3).sub.2, wherein R is an alkyl.

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