Standardized swallow challenge medium and method of use for...

Surgery – Diagnostic testing – Measuring electrical impedance or conductance of body portion

Reexamination Certificate

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C600S593000

Reexamination Certificate

active

10768956

ABSTRACT:
A swallow challenge medium (10) is thixotropic for easy swallowing and to provide enough viscosity for effective challenge to peristalsis (20) and has high ionic density for effective impedance measurements by contact with electrodes (41–48) positioned in a person's esophagus (E) or oropharynx during swallow testing. The medium (10) also has a high surface tension so as not to adhere to or coat the electrodes (41–48) or probe (12) surfaces. These physical characteristics are stabilized and consistent enough to provide standard for esophageal and/or oropharyngeal function testing and diagnostics.

REFERENCES:
patent: 6461589 (2002-10-01), Robbins
patent: 2003/0044351 (2003-03-01), Robbins
Nyugen, N.G., et al.; Am J Gastroenterol 2006;101:2476-2484.
Frieling et al., “Comparision between intraluminal multiple electric impedance measurement and manometry in the human oesophagus”, Neurogastroenterol Mot. (1996) 8, pp. 45-50.
Nguyen et al., “Dynamics of esophageal bolus transport in healthy subjects studied using multiple intraluminal impedancometry”, American Physiological Society (1997), pp. 958-964.
Jiri Silny, “Intraluminal Multiple Electric Impedance Procedure for Measurement of Gastrointestinal Motility”, Journal of Gastrointestinal Motility (1991), pp. 151-162.
Fass et al., “Measuring Esophageal Motility with a New Intraluminal Impedance Device”, Scand Journal of Gastroenterology (1994), pp. 693-702.

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