Stable, water soluble salt compositions of M-AMSA in 1-methyl-2-

Details Stable, water soluble salt compositions of M-AMSA in 1-methyl-2- Stable, water soluble salt compositions of M-AMSA in 1-methyl-2-

1985-12-12

1991-07-23

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

050343971

ABSTRACT:
This invention relates to novel compositions of the antitumor agent [4'-9-(acridinylamino) methanesulfon-m-anisidide], (m-AMSA). Acid salts of m-AMSA are dissolved in 1-methyl-2-pyrrolidinone to provide highly stable solutions. The solutions may be diluted with Sterile Water for Injection, U.S.P. to provide stable, non-precipitating solutions for intravenous use.

REFERENCES:
patent: 4425348 (1984-01-01), Kaplan et al.
patent: 4575509 (1986-03-01), Chen et al.

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