Stable warfarin sodium liquid formulation and method of...

Details Stable warfarin sodium liquid formulation and method of... Stable warfarin sodium liquid formulation and method of...

2007-08-21

2007-08-21

Dentz, Bernard (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S286000

Reexamination Certificate

active

11453757

ABSTRACT:
A stable liquid composition comprising warfarin sodium, glycerin, an alcohol such as ethanol, and a pH buffer such as a phosphate buffer providing a pH above 7 is provided. The stability of the composition is characterized by the amount of warfarin sodium in the composition degraded after 1 month at room temperature, which is 5% or less. A method for preparing the composition and a method for providing an anti-coagulant therapy are also disclosed.

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“Coumadin® Tablets; Coumadin® for Injection,” XP-002409141 (Dec. 14, 2004).

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