Stable vitamin C preparation

Details Stable vitamin C preparation Stable vitamin C preparation

1998-10-28

2000-07-04

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30762

Patent

active

060841109

DESCRIPTION:

BRIEF SUMMARY
1. Technical Field
The present invention relates to a stable vitamin C preparation which is used in the field of medicine and the like.
2. Prior Art
Recently, in maintenance of patient's life, total parenteral nutrition is employed for nutritional supplement in patients unable to take nutrition orally or enterally, or insufficient in oral intake, or, if possible, in patients extremely poor in the digestion and absorption functions or patients whose underlying diseases may be aggravated by passing of the food through the digestive tract. Such treatment is often accompanied by vitamin preparations containing various vitamins necessary for man.
Many vitamins are, however, unstable per se, and addition of vitamins to an infusion preparation is done immediately before administration to the patients in consideration of the stability of the preparation after addition. Above all, vitamin C (ascorbic acid) is known to be easily decomposed in the presence of oxygen, water, or metal ions such as copper ion or iron ion. From such viewpoint, the stabilization of vitamin C in a vitamin C preparation is an important problem in pharmaceutical technology.
The present inventors attempted various investigations about stabilization of vitamin C in an aqueous solution, and discovered that vitamin C is stabilized in the presence of magnesium ions, which has led to the completion of the invention.


DISCLOSURE OF THE INVENTION

The invention provides a stable vitamin C preparation composed of a vitamin C preparation blended with magnesium ions. In this vitamin C preparation, magnesium ions are preferably contained by 14 parts by weight or more in 100 parts by weight of vitamin C. The vitamin C preparation can be an infusion preparation containing vitamin C. In this case, the vitamin C preparation can be one blended magnesium ions as an electrolyte infusion solution containing magnesium ions, and one blended an electrolyte infusion solution at magnesium ion concentration of 1.5 to 5.0 mEq/liter. Moreover, the vitamin C preparation can be one blended an electrolyte infusion solution containing magnesium ions at magnesium ion concentration of 15 to 35 mEq/liter and further containing at least one component selected from the group consisting of amino acids, sugars and fats.
The invention also relates to a stabilizing method of vitamin C preparation by blending magnesium ions with the vitamin C preparation, and magnesium ions may be blended as an electrolyte infusion solution containing magnesium ions.
In the invention, since magnesium ions having the effect of stabilizing vitamin C are blended, a vitamin C preparation stable for a long period can be obtained.


BRIEF DESCRIPTION OF THE DRAWING

FIG. 1 is a graph showing the residual rate (%) of ascorbic acid after sterilization in Example 1.


BEST MODE FOR CARRYING OUT THE INVENTION

In the invention, the vitamin C preparation is a pharmaceutical preparation containing vitamin C as ingredient, and various forms of preparations are included, and preferably liquid and freeze-dried preparations are exemplified, and more preferably an infusion preparation containing vitamin C is exemplified. The above-mentioned vitamin C includes derivatives of vitamin C, and specific examples include, aside from ascorbic acid, palmitate ascorbate and dipalmitate ascorbate.
Contents of vitamin C to be contained in the vitamin C preparation are not particularly limited, and may be selected appropriately. For example, the daily required amount per person is presented as a recommended value in the literature, such as The Journal of Japanese Society for Parenteral and Enteral Nutrition, Vol. 13, No. 4, p. 317, 1991, and the content may be determined so that the daily required amount may be taken. More specifically, 30 to 2000 mg may be contained.
Further, the vitamin C preparation of the invention is not intended to exclude blending of other components such as vitamins (e.g. vitamin A, vitamin B1, etc.), sugars, amino acids, and electrolytes.
As magnesium ions in the invention, various magnesium salts such

REFERENCES:
patent: 5626880 (1997-05-01), Inoue et al.
patent: 5674527 (1997-10-01), Inoue et al.
patent: 5728681 (1998-03-01), Kido et al.
patent: 5770233 (1998-06-01), Kido et al.
patent: 5993863 (1999-11-01), Kikuchi et al.

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