Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Rodent cell – per se
Patent
1995-05-08
1998-05-12
Guzo, David
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Rodent cell, per se
435366, 4353201, 536 2372, 536 241, C12N 510, C12N 508
Patent
active
057503966
ABSTRACT:
The field of the invention is recombinant packaging and producer cell lines for producing infectious retroviral vectors. The invention more specifically relates to the generation of pseudotyped retroviral vectors with a broad host range which can be produced at high titers in specially constructed packaging cell lines. Most specifically, the invention relates to the generation of pseudotyped retroviral vectors having vesicular stomatitis virus-G protein (VSV-G) as the membrane-associated viral envelope protein.
REFERENCES:
Gossen, M. et al., "Tight control of gene expression in mammalian cells by tetracycline-responsive promoters," Proc. Natl. Acad. Sci. USA 89: 5547-5551 Jun. (1992).
Yang, Y. et al., "Vesicular Stomatitis Virus (VSV) Pseudotyped Murine Retrovirus Mediates Gene Transfer Into Human Hematopoietic Cells " Blood 84(10); Suupl. I:358a Dec. (1994) Abstract No. 1417.
Yee, J. et al., "A general method for the generation of high-titer, pantropic retroviral vectors: Highly efficient infection of primary hepatocytes," Proc. Natl. Acad. Sci. USA 91:9564-9568 Sep. (1994).
Grosveld Gerard C.
Nienhuis Arthur W.
Vanin Elio F.
Yang Yanping
Genetic Therapy, Inc.
Guzo David
St. Jude's Children's Research Hospital
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