Stable variant hK2 polypeptide

Details Stable variant hK2 polypeptide Stable variant hK2 polypeptide

1996-03-26

2000-08-15

Eyler, Yvonne

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

530324, 530350, A61K 3900, A61K 3800, C07K 100

Patent

active

061032379

ABSTRACT:
An isolated, purified variant hK2 polypeptide useful in preparing immunogenic compositions and vaccines is provided. The variant hK2 polypeptides are more stable to purification than wild type mature hK2 polypeptide.

REFERENCES:
patent: 3817837 (1974-06-01), Rubenstein et al.
patent: 3842067 (1974-10-01), Sarantakis
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 3862925 (1975-01-01), Sarantakis et al.
patent: 3901654 (1975-08-01), Gross
patent: 3935074 (1976-01-01), Rubenstein et al.
patent: 3972859 (1976-08-01), Fujino et al.
patent: 3984533 (1976-10-01), Uzgiris
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4034074 (1977-07-01), Miles
patent: 4092408 (1978-05-01), Litt
patent: 4098876 (1978-07-01), Piasio et al.
patent: 4105602 (1978-08-01), Colescott et al.
patent: 4353982 (1982-10-01), Gomez et al.
patent: 4371515 (1983-02-01), Chu
patent: 4446122 (1984-05-01), Chu et al.
patent: 4487715 (1984-12-01), Nitecki et al.
patent: 4629783 (1986-12-01), Cosand et al.
patent: 4757048 (1988-07-01), Lewicki et al.
patent: 4792528 (1988-12-01), Canfield et al.
patent: 5516639 (1996-05-01), Tindall et al.
P. Altman, et al., "Inbred and Genetically Defined Strains of Laboratory Animals", Biological Handbooks, III, Federation of American Societies for Experimental Biology, pp. 21 and 29.
P. Andrews, et al., "Tumor-promoting Phorbol Ester Down-Regulates the Androgen Induction of Prostate-specific Antigen in a Human Prostatic Adenocarcinoma Cell Line," Cancer Research, 52, 1525-1529 (Mar., 1992).
A. Angermann, et al., "Purification and characterization of human salivary-gland prokallikrein from recombinant baculovirus-infected insect cells", Eur. J. Biochem., 206, 225-233 (1992).
A. Baker, et al., "Human Kidnay Kallikrein: cDNA Cloning and Sequence Analysis", DNA, 4, 445-450 (1985).
T. Berg, et al., "A Common Nomenclature for Members of the Tissue (Glandular) Kallikrein Gene Families", In: Recent Progress on Kinins, Birkhauser Verlag, Basel, pp. 19-25 (1992).
D. P. Bridon, et al., "Structural Comparison of Prostate-Specific Antigen and Human Glandular Kallikrein Using Molecular Modeling", Urology, 45, 801-806 (1995).
C. Chang, et al., "Solid Phase Peptide Synthesis Using Mild Base Cleavage of N.alpha.-Fluorenylmethyloxycarbonylamino Acids, Exemplified by a Synthesis of Dihydrosomatostatin," Int. J. Pept. Pro. Res., 11, 246-249 (1978).
P. Chapdelaine, "High Level of Expression in the Prostate of a Human Glandular kallikrein mRNA Related to Prostate-Specific Antigen", FEBS Lett., 236, 205-208 (1988).
A. Christensson, et al., "Enzymatic Activity of Prostate-Specific Antigen and its Reactions with Extracellular Serine Proteinase Inhibitors", Eur. J. Biochem., 194, 755-763 (1990).
A. Christensson, et al., "Serum Prostate Specific Antigen Complexed to .alpha.1-Antichymotrypsin as an Indicator of Prostate Cancer", J. Urol., 150, 100-105 (1993).
J. Clements, "The Glandular Kallikrein Family of Enzymes: Tissue-Specific Expression and Hormonal Regulation", Endocr. Rev., 10, 393-419 (1989).
J. A. Clements, et al., "The Human Kallikrein Gene Family: A Diversity of Expression and Function", Mol. Cell Endocrinol., 99, c1-6 (1994).
P. Cohen, et al., "Biological Effects of PSA as an IGFBP-3 Protease", In: Program and Abstracts, 74th Annual Meeting of the Endocrine Society, San Antonio, TX, p. 291, Abstract No. 960 (Jun. 1992).
M. Digby, et al., "Human prostate specific antigen (PSA) gene: structure and linkage to the kallikrein-like gene", Nuc. Acids Res., 17, 2137 (1989).
B. Evans, et al., "Structure and Chromosomal Localization of the Human Renal kallikrein Gene", Biochemistry, 27, 3124-3129 (1988).
D. Fukushima, et al., "Nucleotide Sequence of Cloned DNA for Human Pancreatic Kallikrien", Biochemistry, 24, 8037-8043 (1985).
P. Henttu, et al., "cDNA Coding for the Entire Human prostate Specific Antigen Shows High Homologies to the Human Tissue Kallikriein Genes", Biochemical and Biophysical Research Communications, 160, 903-910 (Apr. 28, 1989).
P. Henttu, et al., "Expression of the Gene Coding for Human Prostate-Specific Antigen and Related hGK-1 in Benign and Malignant Tumors of the Human Prostate," Int. J. Cancer, 45, 654-660 (1990).
C. S. Hill, et al., "The Preparation of Monoclonal Antibodies Which React Preferentially with Human Bone Alkaline Phosphates and not Liver Alkaline Phosphatase," Clinica Chemica Acta, 186, 315-320 (1989).
T. H. Jones, et al., "Bioregulatory Role of the Kallikrein-Kinin System in the Normal Pituitary Gland and Its Tumours," Acta Endocrinol., 127, 481-484 (1992).
C. Killian, et al., "Mitogenic Response of Osteoblast Cells to Prostate-Specific Antigen Suggests an Activation of Latent TGF-6 and a Proteolytic Modulation of Cell Adhesive Receptors," Biochem. Biophys. Res. Comm., 192, 940 (1993).
J. Leinonen, et al., "Double-Label Time-Resolved Immunofluorometric Assay of Prostate-Specific Antigen and of its Complex with .alpha.1-Antichymotrypsin," Clin. Chem., 39, 2098-2103 (1993).
J. Lovgren, et al., "Production of Recombinant PSA and HK2 and Analysis of Their Immunologic Cross-Reactivity," Biochem. Biophys. Res. Comm., 231, 888-895 (1995).
H. Lu, et al., "Human urinary Kallikrein", Int. J. Peptide Protein Res., 33, 237-249 (1989).
A. Lundwall, et al., "Molecular cloning of human prostate specific antigen cDNA", FEBS Lett., 214, 317-322 (Apr., 1987).
A. Lundwall, "Characterization of the gene for Prostate-specific antigen, a human glandular kallikrein", Biochem. Biophys. Research Comm., 161, 1151-1159 (Jun., 1989).
R. McCormack, et al., "Molecular Forms of Prostate-Specific Antigen and the Human Kallikrein Gene Family: A New Era", Urology, 45, 729-744 (May 1995).
B. Montgomery, et al., "Hormonal Regulation of Prostate-Specific Antigen (PSA) Glycoprotein in the Human Prostatic Adenocarcinoma Cell Line, LNCaP", The Prostate, 21, 63-73 (1992).
B. Morris, "hGK-1: A Kallikrein Gene Expressed in Human Prostate", Clin. Exp. Pharmacol. Physiol, 16, 345-351 (1989).
P. Murtha, et al., "hGK-1: A Kallikrein Gene Expressed in Human Prostate," Biochemistry, 32, 6459-6464 (1993).
G. Paradis, et al., "Looking for Human Glandular Kallikrein-1 in the Prostate", The Prostate, 15, 343-353 (1989).
S. Qui, et al., "In Situ Hybridization of Prostate-Specific Antigen mRNA in Human Prostate", J. Urology, 144, 1550-1556 (1990).
P. Riegman, et al., "Characterization of the Prostate-Specific Antigen Gene: A Novel Huamn Kallikrein-Like Gene", Biochem. Biophys. Res. Comm., 159, 95-102 (Feb., 1989).
P. Riegman, et al., "The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19", FEBS Lett., 247, 123-126 (Apr., 1989).
P. H. Riegman, et al., "Identification and androgen-regulated expression of two major human glandular kallikrein-1 (hGK-1) mRNA species", Molecular and Cellular Endocrinology, 76, 181-190 (1991).
M. S. Saedi, et al., "Overexpression of a human prostate-specific glandular kallikrein hK2, in E. coli and generation of antibodies", Molecular and Cellular Endocrinology, 109, 237-241 (Feb., 1995).
L. J. Schedlich, et al., "Kallikrein Genes: Cloning in Man and Expression in Rat Renal Hypertension", Journal of Hypertension Supplement, 6, S395-S398 (Dec., 1988).
L. Schedlich, et al., "Primary Structure of a Human Glandular Kallikrein Gene", DNA, 6, 429-437 (1987).
L. J. Schedlich, et al., "Three Alu Repeated Sequences Associated with a Human Glandular Kallikrein Gene", Clin. Exper. Pharmacology & Physiology, 15, 339-344 (1988).
P. Schulz, et al., "Sequence of a cDNA clone encompassing the complete mature human prostate specific antigen (PSA) and an unspliced leader sequence," Nuc. Acids Res., 16, 6226 (1988).
G. Sutherland, et al., "Human prostate-specific antigen (APS) is a member of the glandular kallikrein gene family at 19p13", Cytogenet. Cell Genet., 48, 205-207 (1988).
M. Vinhinen, "Modeling of Prostate Specific Antigen and Human Glandular Kallikrein Structures," Biochem. Biophys. Res. Comm., 204, 1251-1256 (1994).
J. Wang, et al., "Purification and Characterization of recombinant tissue kallikrein from Escherichia coli and yeast

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