Stable topical ascorbic acid compositions

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

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424 7012, 424 40L, A61K 914

Patent

active

061466646

ABSTRACT:
An ascorbic acid (Vitamin C) composition in a nonaqueous or substantially anhydrous silicone vehicle has superior stability. Particulate ascorbic acid is substantially insoluble in the disclosed polyorganosiloxane vehicles, and the vehicle substantially excludes environmental oxygen. The ascorbic acid particles have surprisingly been found to have a high degree of bioavailability and effectiveness, for example in topical applications to reduce wrinkles and increase collagen growth and elasticity.

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Darr et al., Topical Vitamin C Protects Porcine Skin From Ultraviolet Radiation-Induced Damage, British Journal of Dermatology 127:247-253 (1992).
Gensler et al., Importance of the Form of Topical Vitamin E for the Prevention of Photocarcinogenesis, Nutrition and Cancer 26:183-191 (1996).
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