Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants
Patent
1995-01-10
1997-04-01
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Biocides; animal or insect repellents or attractants
514557, 5147724, A01N 2502, A61K 4732, A61K 3119
Patent
active
056163355
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to aqueous disinfectant compositions which are stable with time, non-irritant and have a wide antimicrobial spectrum, as well as to their uses, in particular as hygiene agents.
Numerous compositions intended for disinfection of the skin or of mucous membranes have already been marketed. Such compositions may be in liquid form and contain quarternary ammonium compounds such as chlorhexidine derivatives like chlorhexidine digluconate or compounds such as parachloromethacresol or trichlorocarbanilide as disinfecting or antiseptic agent.
These compositions usually contain various surface-active agents with a view, in particular, to favouring cleaning of the skin. They are then collectively known as "antiseptic liquid soap". However, these compositions have the main disadvantages, on the one hand, of having an antimicrobial spectrum which is limited to certain microbial populations generally chosen from Gram-positive or Gram-negative bacteria, microfungi such as yeasts or moulds, or viruses, and, on the other hand, of making possible only a small decrease in the number of a given microbial population, that is to say of having only a reduced disinfecting or antiseptic power. In order to overcome the latter disadvantage it is usually recommended to leave the disinfectant composition in contact with the skin or the mucous membrane to be disinfected for several minutes; however, even so, the decrease in the microbial population often remains insufficient. Furthermore, in common practice, it has been possible to observe that a user rarely exceeds a contact time of one minute, this contact time being more generally of the order of 30 seconds.
A need was thus expressed for disinfectant compositions having a wide antimicrobial spectrum and a strong disinfecting power which is rapidly manifested, in all cases in less than one minute and preferably in less than 30 seconds.
Moreover, it is known that organic peroxy acids have a disinfecting or antimicrobial power. Organic peroxides are usually used for the disinfection of floors and other surfaces. They are also used for the disinfection of articles which are intended to come into contact with a biological medium. Thus, aqueous solutions of peroxy acids have been described in Patent Application EP-A-472,713 as a disinfecting agent for milk vats, in Patent Application EP-A-370,850 as a disinfecting agent for haemodialysis devices or in Patent Applications GB 2,255,507 and EP-A-421,974 as a disinfectant for large volumes which are not easily immersed and for non-horizontal surfaces. For the purpose of disinfection of such articles, the peroxy acid concentration of the disinfecting agent is always greater than 0.1% by weight, and more generally greater than 1% by weight. On account in particular of their aggressive and irritant nature, it is advisable to remove carefully, by washing with water, all trace of peroxy acids from the disinfected articles before they are placed in contact with a biological medium such as milk or blood. It is also on account of their aggressive and irritant nature for the skin and the mucous membranes that, to the knowledge of the Applicant, no disinfectant composition intended in particular for human or animal body hygiene has hitherto been marketed.
Moreover, the Applicant has been able to show that, on account of their strong oxidizing power, organic peroxy acids may degrade other additives such as surface-active agents, which it is often convenient to which are often incorporated into a composition of the antiseptic liquid soap type. Conversely, certain surfactants may sometimes rapidly degrade organic peroxy acids and cause them to lose their disinfectant properties.
The Applicant has also been able to show that these compositions containing certain additives such as surface-active agents and organic peroxy acids, while having a homogeneous appearance for a short period, may dissociate into at least two phases after a few months, or even a few weeks.
Now, compositions intended for human or animal use, which are ab
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Crisinel Pascal
Declerck Gerard
Le Rouzic Daniel
Ledon Henry
Nicolle Remy
Azpuru Carlos A.
Chemoxal S.A.
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