Stable therapeutic radionuclide compositions and methods for pre

Details Stable therapeutic radionuclide compositions and methods for pre Stable therapeutic radionuclide compositions and methods for pre

1994-11-21

1997-10-21

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 145, 424 153, 424 169, 424 147, A61K 5100

Patent

active

056793189

ABSTRACT:
Stable therapeutic radionuclide compositions comprising, for example, .sup.186 Re, .sup.188 Re and .sup.131 I stably bound to a proteinaceous targeting moiety and suitable for human in vivo administration are disclosed. Stabilizing agents preferably comprise antioxidants and challenging agents, and combination of HSA with an antioxidant and/or challenging agent provides enhanced long term stability. Ascorbic acid is an especially preferred stabilizing agent, which provides stability of therapeutic radionuclide compositions at levels of at least about 90% for several hours up to several days.

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Kishore et al., Nucl. Med. Biol., vol. 13, No. 4, pp. 457-459 1986.

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