Stable therapeutic oil filled soft gelatin capsules

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules

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4241951, 424455, 424451, 514557, 514558, 514560, 514962, A61K 948

Patent

active

055652140

ABSTRACT:
The invention relates to a process for the preparation of therapeutically useful, highly stable soft gelatine capsules containing native oils obtained in the case of vegetable oils by the cold pressing of mainly plant parts, such as seeds, which comprises adjusting the free fatty acid content of the oil to an acid number of from about 0.3 to about 4.5 by mixing oils of identical or different natural source with a different acid number not in excess of about 4.5 and then filling the oil into soft gelatine capsules aromatized from about 0% to about 10% by mass of a perfume.

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Burton et al. Human Nutrition p. 197 1988 4th Edition.
Grant & Hacktis Chemical Dictionary, 5th Edititon McGraw Hill, Grant et al., p.10 acid value.
Textbook of Biochemistry West et al. 4th Edition, MacMillan, pp. 142-145, 765, 766.
Kirk-Othmer "Encyclopedia of Chemical Technology" Third Edition, vol. 9 (1980).

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