Stable solutions of rebeccamycin analog

Details Stable solutions of rebeccamycin analog Stable solutions of rebeccamycin analog

1989-05-10

1996-03-05

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 42, 536 271, A61K 3171, C07H 1904

Patent

active

054968097

ABSTRACT:
Stable solutions of rebeccamycin analog consist essentially of (a) water, (b) 8-N-(diethylaminoethyl)rebeccamycin in an effective dosage amount, and (c) pharmaceutically acceptable acid such that the presence of a molar equivalence thereof would solubilize (b), said acid being present in excess of said molar equivalence to provide a stabilizing pH ranging from 3 to 4, preferably from 3.0 to 3.6. A preferred solution contains 10 mg/ml of the free base and tartaric acid in equimolar amount with the free base to provide a pH of 3.5. Preferably, the solution is prepared by forming a suspension of 8-N-(diethylaminoethyl)rebeccamycin in water and adding acid to provide a pH ranging from 3 to 4.

REFERENCES:
patent: 4785085 (1988-11-01), Kaneko et al.
patent: 4808613 (1989-02-01), Kaneko et al.
Shriner et al. The Systematic Identification of Organic Compounds. John Wiley & Sons (New York: 1965), pp. 72-87.
Lehninger, A. L. Biochemistry: The Molecular Basis of Cell Structure and Function. Worth Publishers, Inc. (Johns Hopkins University, 1975), pp. 48-53.

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