Stable solutions of rebeccamycin analog

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 42, 536 271, A61K 3171, C07H 1904

Patent

active

054968097

ABSTRACT:
Stable solutions of rebeccamycin analog consist essentially of (a) water, (b) 8-N-(diethylaminoethyl)rebeccamycin in an effective dosage amount, and (c) pharmaceutically acceptable acid such that the presence of a molar equivalence thereof would solubilize (b), said acid being present in excess of said molar equivalence to provide a stabilizing pH ranging from 3 to 4, preferably from 3.0 to 3.6. A preferred solution contains 10 mg/ml of the free base and tartaric acid in equimolar amount with the free base to provide a pH of 3.5. Preferably, the solution is prepared by forming a suspension of 8-N-(diethylaminoethyl)rebeccamycin in water and adding acid to provide a pH ranging from 3 to 4.

REFERENCES:
patent: 4785085 (1988-11-01), Kaneko et al.
patent: 4808613 (1989-02-01), Kaneko et al.
Shriner et al. The Systematic Identification of Organic Compounds. John Wiley & Sons (New York: 1965), pp. 72-87.
Lehninger, A. L. Biochemistry: The Molecular Basis of Cell Structure and Function. Worth Publishers, Inc. (Johns Hopkins University, 1975), pp. 48-53.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Stable solutions of rebeccamycin analog does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stable solutions of rebeccamycin analog, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stable solutions of rebeccamycin analog will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1413034

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.