Stable solutions of hydrogenated ergotalkaloids

Details Stable solutions of hydrogenated ergotalkaloids Stable solutions of hydrogenated ergotalkaloids

1981-11-02

1983-09-06

Rosen, Sam

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated to proteinaceous toxin or fragment thereof

424261, A61K 31725, A61K 3148

Patent

active

044029497

ABSTRACT:
Stable solutions of (a) hydrogenated ergot alkaloids and (b) heparin as well as the salts thereof in a carrier medium comprising (c) water, (d) a mono- or poly-alcohol, and (e) urea or a pharmaceutically acceptable calcium or magnesium salt or ethylenediaminetetraacetic acid, and combinations thereof.

REFERENCES:
patent: 2269145 (1942-01-01), Cutler et al.
patent: 3030272 (1962-04-01), Schultz
patent: 4069185 (1978-01-01), Sullivan
patent: 4087567 (1978-05-01), Sullivan
patent: 4090977 (1978-05-01), Dubin
patent: 4112925 (1978-09-01), Sullivan
patent: 4138565 (1979-02-01), Ehrhardt
patent: 4196196 (1980-04-01), Tiholiz
Bergogne, Revue de l'Atherosclerose, (Paris), 10 (2), 11-13, (1968).
Windsor et al., Nature 190, 263-4, (1961).
Fiedler, Lexikon der Hilfsstoffe 1971, 25-26.
Merck Index, 9th Ed., 1663, (1976).
Sandoz Package Insert--"Heparin-Dihydergot.RTM.".

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