Stable solid preparation of thiol ester derivative

Details Stable solid preparation of thiol ester derivative Stable solid preparation of thiol ester derivative

1987-01-16

1988-11-08

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424149, 514408, A61U 3140, A61U 3179, A61U 3320

Patent

active

047833343

ABSTRACT:
A stable solid thiol ester derivative preparation which contains as active ingredients a thiol ester derivative or a salt thereof, a water-soluble wax which is solid at ordinary temperatures, and sodium carboxymethyl starch and/or a monovalent electrolyte. Thiol ester derivatives are very useful as drugs but, in a solid state, they are sensitive to moisture. A stable solid preparation of thiol ester derivative is obtained by mixing the above additives and/or a monovalent electrolyte into a thiol ester derivative.

REFERENCES:
patent: 4283407 (1981-08-01), Malen
Tanaka, S; Kuromaru, K; Fujimura, Y; Matsunaga, S; Iwaoka, T; Obatake, N; Aono, J; Hinohara, Y; Nakano, H; et al. (Chugai Pharm. Co. Ltd. Belg. BE 893,553, Chem Abstract 98:215995N Proline Derivatives.
Ryan, J. W., Chung, A. Antihypertensive Mercapto Aczl-Amino Acid Derivatives and Their Use, Chem. Abstract 94:16080C.
McTaggart et al, "The Evaluation of Formulation and Processing Conditions of Melt Granulation Process", Int. J. of Pharmaceutics, 19 (1984), pp. 139 to 148.
Shah et al, "Polyethylene Glycol as a Binder for Tablets", J. of Pharmaceutical Sc., vol. 66, No. 11, Nov. 1977, pp. 1551-1552.
Bolhuis et al, "Interaction of Tablet Disintegrants and Magnesium Stearate During Mixing I: Effect on Tablet Disintegration", J. of Pharmaceut. Sc., vol. 70, No. 12, Dec. 1981, pp. 1328-1330.
"Sodium Starch Glycolate", Explotab, Edward Mendell Co., Inc. Carmel, N.Y. 10512.

Affiliated with

Also associated with

Rating

Stable solid preparation of thiol ester derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stable solid preparation of thiol ester derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stable solid preparation of thiol ester derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-463266