Stable solid pharmaceutical compositions containing enalapril ma

Details Stable solid pharmaceutical compositions containing enalapril ma Stable solid pharmaceutical compositions containing enalapril ma

1994-07-15

1996-10-08

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

514 19, 514 21, 514 23, 514 58, 514558, 514960, A61K 920, A61K 3800, A61K 3170, A61K 31715

Patent

active

055629210

ABSTRACT:
Enalapril maleate is unstable when associated with many excipients commonly used in the manufacture of pharmaceutical compositions. Stable solid compositions are provided by mixing enalapril maleate into a carrier that is comprised primarily of water-soluble carbohydrates and contains a lubricant other than magnesium stearate, a preferred lubricant being zinc stearate.

REFERENCES:
patent: 4374829 (1983-02-01), Harris et al.
patent: 4973470 (1990-11-01), Mills et al.
The Merck Index, Tenth Edition (1983), p. 645, abstract no. 4352.

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