Stable solid formulation of enalapril salt and process for prepa

Details Stable solid formulation of enalapril salt and process for prepa Stable solid formulation of enalapril salt and process for prepa

1995-08-04

1996-11-12

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424465, 514960, 514970, A61K 920

Patent

active

055737803

ABSTRACT:
There is disclosed a stable pharmaceutical solid composition comprising enalapril as the sodium salt, which is made by the steps of:
i) mixing enalapril maleate with a carrier, an alkaline sodium compound, and water
ii) drying the wet mass, and;
iii) further processing the resultant dried mass into tablets.
When the water is added in the aforesaid process, an acid-base reaction occurs which converts the enalapril maleate into the more stable enalapril sodium salt.

REFERENCES:
patent: 4374829 (1983-02-01), Harris et al.
patent: 4743450 (1988-05-01), Harris et al.
patent: 5350582 (1994-09-01), Merslavic et al.

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