Stable small particle liposome preparations, their production an

Details Stable small particle liposome preparations, their production an Stable small particle liposome preparations, their production an

1995-04-27

1996-03-12

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424401, A61K 9127

Patent

active

054984203

ABSTRACT:
The invention relates to liposome preparations with controllable vesicle size and type between about 20 and 150 nm and high stability without increased permeability, the vesicle membrane of the liposomes consisting essentially of lecithin and 10%-90%, preferably 16-90%, and most especially 20-80%, of a specified fatty acid-esterified collagen hydrolysate (FAECH), namely, a fatty acid ester of a lipoaminoacid or lipopeptide, representatively OHAP, plus traditional jellifying agents, adjuvants, and pharmaceutical agents as desired, and the production and use thereof in cosmetic and pharmaceutical compositions, as well as a method of controlling vesicle dimensions and reducing vesicle particle size by employing increased and previously believed inoperative ratios of FAECH to lecithin.

REFERENCES:
patent: 4508703 (1985-04-01), Redziniak
patent: 5008109 (1991-04-01), Tin
USP XXII, NF XVII, cover sheet, index p. v, and pp. 1942 and 1943 relating to lecithin, by USPC, Inc. (1989)--four (4) pages.
Chemical Abstracts Service, Registry Handbook, cover page plus page 2478RG with registry No. 68458-51-5 (1978 Supplement) by CAS (1978)--two (2) pages.
JP-Z: Pat. Abstr. Japan C-721, May 23, 1990, vol. 14/No. 242 (JP 2-63548A).

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