Stable silica-based ether bonded phases for biopolymer separatio

Organic compounds -- part of the class 532-570 series – Organic compounds – Silicon containing

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556444, 528 34, 210656, 435287, 435803, C07F 708, C07F 718

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active

049963430

ABSTRACT:
Fast high resolution separations of biopolymers with retention of biological activity have been achieved by hydrophobic interaction chromatography using trialkoxy silyl ethers of the general formula

REFERENCES:
patent: 2796406 (1957-06-01), Sorensen
patent: 2896458 (1958-08-01), Haluska
patent: 3172899 (1965-03-01), Bailey
H. Engelhardt/D. Mathes, "High Performance Liquid Chromatography of Proteins Using Chemically-Modified Silica Supports" in Chromatographia, vol. 14, No. 6, Jun. 1981, pp. 325-332.
S. A. Cohen, et al., "Multiple Peak Formation in Reversed-Phase Liquid Chromatography of Papain", in Analytical Chemistry, vol. 56, No. 2, Feb. 1984, pp. 217-221.
S. A. Cohen, et al., "Multiple Peak Formation in the Reversed Phase Liquid Chromatographic Separation of Soybean Trypsin Inhibitor" in Affinity Chromatography and Biological Recognition, Academic Press, Inc. 1983, pp. 479-487.

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