Stable reverse and multiple fluorocarbon emulsions

Details Stable reverse and multiple fluorocarbon emulsions Stable reverse and multiple fluorocarbon emulsions

1995-06-07

1999-05-18

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424455, 514832, 514937, 514938, A61K9/127

Patent

active

059049332

ABSTRACT:
Stable reverse water-in-fluorocarbon emulsions and water-in-fluorocarbon-in-water multiple emulsions comprising the reverse fluorocarbon emulsions. The reverse emulsions comprise a continuous phase which is a highly fluorinated or perfluorinated compound, a discontinuous aqueous phase and a fluorinated surfactant or mixture of surfactants. The multiple emulsions comprise an aqueous continuous phase and a discontinuous phase comprising globules formed of aqueous droplets dispersed into a highly fluorinated or perfluorinated compound. The emulsions can contain pharmacologically active agents, and are particularly suitable for pulmonary drug delivery.

REFERENCES:
patent: 3975512 (1976-08-01), Long
patent: 4917930 (1990-04-01), McCormick
J.G. Riess, (1991) Fluorocarbon-based in vivo oxygen transport and delivery systems. Vox Sang 61:225-239.
J.G. Riess, (1991) Hemocompatible fluorocarbon emulsions. Blood Compatible Materials and Devices, Chapter 14, 237-270.
T.H. Shaffer, et al., (1992) Liquid Ventilation. Pediatric Pulmonolgy 14:102-109.
T.H. Shaffer, et al., (1994) Perfluorochemical liquid as a respiratory medium. Art, Cells, Blood Subs., and Immob. Biotech. 22(2):315-326.
Kogyo, T. (1982) Magnetic fluid containing carcinostatic agent. Patent Abstracts of Japan 6(202) (C-129) Derwent Publications Ltd., London, GB.

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