Stable radiometal antibody immunoconjugates

Details Stable radiometal antibody immunoconjugates Stable radiometal antibody immunoconjugates

1991-11-04

1994-08-02

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562507, 564462, C07D20746, C07C28102

Patent

active

053347293

ABSTRACT:
The present invention relates to new rigid chelating structures, to methods for preparing these materials, and to their use in preparing radiometal labeled immunoconjugates. These new chelates include cyclohexyl EDTA monohydride, the trans forms of cyclohexyl DTPA and TTHA, and derivatives of these cyclohexyl polyaminocarboxylate materials.

REFERENCES:
patent: 4352751 (1982-10-01), Wieder et al.
patent: 4707440 (1987-11-01), Stavrianopoulos
Takeshita, et al., JAOCS, 59, No. 2 (Feb. 1982).

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