Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-04-19
1995-12-05
Parr, Margaret
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4351722, 435 702, C12N 526, C12N 520
Patent
active
054728681
ABSTRACT:
A stable xenogeneic fusion partner that is a product of the fusion of a mouse myeloma cell and a non-transformed rabbit partner cell. The fusion partner produces undetectable levels of antibody, as determined by an enzyme linked immunosorbent assay. A method for generating rabbit monoclonal antibodies is disclosed that comprises fusing a nontransformed rabbit partner cell with a rodent myeloma cell to produce a xenogeneic fusion partner, selecting a stable fusion partner producing undetectable levels of antibodies, fusing the stable fusion partner with a rabbit antibody producing cell and isolating an antibody producing cell line that produces antibodies directed to a predetermined antigen.
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Liu Ru-shya
Manetta Joseph V.
McCormack Robert T.
Sportsman John R.
Eli Lilly & Company
Krikorian Jacqueline G.
Parr Margaret
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