Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1995-03-31
1999-02-23
Ulm, John
Drug, bio-affecting and body treating compositions
Lymphokine
530351, 930140, 930145, 424450, A61K 3819, A61K 9127, C07K 1452, C07K 14535
Patent
active
058740759
ABSTRACT:
The invention relates to stable compositions of proteins and related methods wherein a protein capable of transitioning into the molten globular state is contacted with a negatively charged lipid vesicle, thereby stabilizing the protein against thermally-induced aggregation, denaturation, and loss of activity. The protein:phospholipid complex directly stabilizes the secondary and tertiary structure of the protein, and the compositions are useful in high temperature formulations and in novel delivery vehicles.
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Brems David
Cha Younsik
Collins David
Amgen Inc.
Crandall Craig A.
Levy Ron K.
Odre Steven M.
Saoud Christine
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