Stable prostaglandin E gels utilizing colloidal silicon dioxide

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514944, A61K 3119, A61K 31557

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active

046803122

ABSTRACT:
The present invention provides an improved class of stable gels of prostaglandin E compounds prepared from solutions of prostaglandin E compounds in a pharmaceutically acceptable, stabilizing organic solvent, e.g., triacetin, gelled by the addition of colloidal silicon dioxide.

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Calder, A. A., et al., "Ripening of a Cervix with Extra Amniotic Prostaglandin E.sub.2 in Viscous Gel Before Induction of Labor," Brit. J. OB/GYN, 84:264-268 (1977).
Eros, I., et al., "Applications of Colloidal Silicon Dioxide in Pharmaceutical Technology, II, Gysgyszereszet 19(8), 290-5 (1975), Chem. Abstracts 83:18331q (1975).
M. Sherriff and R. P. Enever, "Rheological and Drug Release Properties of Oil Gels Containing Coloidal Silicon Dioxide," J. Pharm. Sci., 68(7), 842-845 (1979).

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