Stable pro-drug forms of theophylline

Details Stable pro-drug forms of theophylline Stable pro-drug forms of theophylline

1976-10-18

1978-04-18

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260256, A61K 3152, C07D47308

Patent

active

040852148

ABSTRACT:
There is provided exceptionally stable and useful pro-drug forms of theophylline having the formula: ##STR1## wherein R represents a straight or branched phenylalkenyl group having 2-8 carbon atoms in the alkenyl portion.
The compounds of this invention are useful in the treatment of asthma in warm-blooded animals. Upon administration, the compounds of this invention slowly go into solution and subsequently cleave prior to and/or during the absorption process, releasing theophylline in a sustained manner at a non-toxic, therapeutic level; that is, without the large blood level variations normally observed when theophylline per se is administered.

REFERENCES:
patent: 2729643 (1956-01-01), Stoll et al.
patent: 3737433 (1973-06-01), Mohler et al.
patent: 3813394 (1974-05-01), Tensho et al.
patent: 3935196 (1976-01-01), Higuchi et al.

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