Stable polymorphic forms of an anticonvulsant

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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07667042

ABSTRACT:
Stable polymorphic forms III, IV and substantially amorphous form of an anticonvulsant, tiagabine hydrochloride.

REFERENCES:
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Chawla et al., CRIPS vol. 5, No. 1, Jan.-Mar. 2004, p. 9-12.
Newman et al., DDT vol. 8, Oct. 2003, p. 898-905.
Byrn et al., “Solid-State Chemistry of Drugs”, 1999, p. 62-63.
Andersen et al. “The Synthseis of Novel GABA Uptake Inhibitors. 1.Elucidation of the Structure-Activity Studies Leading to the Choice of (R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic Acid (Tiagabine) as an Anticonvulsant Drug Candidate” Journal of Medicinal Chemistry, 36 p. 1716-1725 (1993).

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