Stable plurilamellar vesicles

Details Stable plurilamellar vesicles Stable plurilamellar vesicles

1991-04-02

1992-12-08

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

514 2, 514 29, 514 39, 514 41, 514152, 514192, A61K 3722, A61K 3700, A61K 3170, A61K 3165, A61K 3143

Patent

active

051696371

ABSTRACT:
A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for identifying the same. SPLVs are characterized by lipid bilayers enclosing aqueous compartments containing one or more entrapped solutes, the concentration of such solutes in each aqueous compartment being substantially equal to the emunization of solutes used to prepare the SPLVs. The bilayers of SPLVs are substantially non-compressed. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.

REFERENCES:
patent: 4522803 (1985-06-01), Lenk et al.

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