Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1984-10-12
1991-07-09
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
A61K 3722
Patent
active
050304534
ABSTRACT:
A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for identifying the same. SPLVs are characterized by lipid bilayers enclosing aqueous compartments containing one or more entrapped solutes, the concentration of such solutes in each aqueous compartment being substantially equal to the concentration of solutes used to prepare the SPLVs. The bilayers of SPLVs are substantially non-compressed. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.
REFERENCES:
patent: 4522803 (1985-01-01), Lenk et al.
Fountain Michael W.
Ginsberg Richard S.
Gruner Sol M.
Janoff Andrew S.
Lenk Robert P.
Bloom Allen
Friedman Stanley J.
Henley III Raymond J.
Ort Ronald G.
Saunders Thomas M.
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