Stable pharmaceutical solution formulations for pressurized...

Details Stable pharmaceutical solution formulations for pressurized... Stable pharmaceutical solution formulations for pressurized...

2006-03-28

2006-03-28

Kunz, Gary (Department: 1616)

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

C424S043000, C424S434000, C514S340000, C514S630000, C128S200140, C128S200230

Reexamination Certificate

active

07018618

ABSTRACT:
An aerosol solution composition for use in an aerosol inhaler comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility component to increase the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler.The composition is stabilized by using a small amount of mineral acid and a suitable can having part or all of its internal metallic surfaces made of stainless steel, anodized aluminium or lined with an inert organic coating.

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