Stable pharmaceutical compositions of short-acting .beta.-adrene

Details Stable pharmaceutical compositions of short-acting .beta.-adrene Stable pharmaceutical compositions of short-acting .beta.-adrene

1984-04-09

1986-04-01

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514415, 514419, 514522, 514533, 514534, 514535, 514538, A61K 31235, A61K 31405, A61K 31275, A61K 3124

Patent

active

045798672

ABSTRACT:
A pharmaceutical composition for parenteral administration is disclosed which comprises from about 0.01% to about 30% of a .beta.-adrenergic blocking compound of the formula ##STR1## wherein Ar represents a substituted or unsubstituted aromatic group or heterocyclic group; W represents alkylene of from 1 to about 10 carbon atoms; and B represents --NR.sub.2 COR.sub.1, --NR.sub.2 CONR.sub.1 R.sub.3, --NR.sub.2 SO.sub.2 R.sub.1, --NR.sub.2 SO.sub.2 NR.sub.2 R.sub.3, or --NR.sub.2 COOR.sub.1 wherein R.sub.1, R.sub.2 and R.sub.3 may be the same or different and may be hydrogen, alkyl, alkoxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl, except that R.sub.1 is not hydrogen when B is --NR.sub.2 SO.sub.2 R.sub.1 or --NR.sub.2 COOR.sub.1, or R.sub.1 and R.sub.3 may together with N form a 5 to 7 membered heterocyclic group or W and B together denote Z which represents lower alkyl or aralkyl; or a pharmaceutically acceptable salt thereof in a hydroalcoholic solution including from about 5% to about 50% ethanol by volume of a physiologically acceptable polyhydric compound; from about 0.05 to about 2 molar physiologically acceptable buffering agent; said hydroalcoholic solution having a pH of from about 2.0 to about 4.0. The pharmaceutical compositions are useful in the treatment or prophylaxis of cardiac disorders.

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