Stable pharmaceutical composition and method for its production

Details Stable pharmaceutical composition and method for its production Stable pharmaceutical composition and method for its production

1991-12-31

1994-03-29

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

424450, 424491, 514 24, 514678, A61K 3748, A61K 3722, A61K 3700, A61K 3712

Patent

active

052982467

ABSTRACT:
The present invention is directed to a stable pharmaceutical composition wherein the absorbability of a lipophilic drug which is insoluble or practically insoluble in water or another drug such as a bioactive peptide in oral administration has been improved to such extent that a high level of blood concentration can be retained, and to a method for producing such a stable pharmaceutical composition. The pharmaceutical composition of the present invention offers improvements in the absorbability, for example, a high level of blood concentration can be retained for a long time in oral administration because it is highly resistant to lipase. Also, the pharmaceutical composition is highly safe because the emulsifier used is derived from mammalian milk.

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McPherson et al, Journal of Dairy Research, vol. 50, pp. 107-133 (1983).
Chemical Abstracts, vol. 114, No. 12, Abstract No. 108805c (1991).

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