Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-11-02
1995-03-14
Henley, III, Raymond J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3144
Patent
active
053977840
ABSTRACT:
The invention relates to novel, parenterally useful, stable aqueous pharmaceutical compositions, mainly injectable solutions containing a bis-indole alkaloid. The compositions contain the zinc complex of a bis-indole alkaloid, preferably vincristine, vinblastine or 5'-nor-dihydrovinblastine together with a bivalent metal gluconate and a preserving agent dissolved in a mono- or polyhydric alcohol.
The invention further relates to a process for the preparation of the above compositions.
The composition according to the invention can be utilized for the parenteral administration of bis-indole alkaloids in the cancer chemotherapy.
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patent: 4923876 (1990-05-01), Francis et al.
Black et al., J. Pharm. Sci. 77(7):630-634, Jul. 1988. Studies on the stability of vinblastine sulfate in aqueous solution.
Chemical Abstracts 100(16):126905a, 1984, Eli Lily & Co. Aqueous Vinca alkaloid formulations.
Chemical Abstracts, 108(24):210210t, 1988. Leverd et al. Stable aqueous solution of vincristine sulfate.
Chemical Abstracts 108(10):83040k, 1988, Burger et al. Calcium-, Magnesium- and zinc-ion coordination of vincristine.
Gazdag Maria
Kiss Eva E.
Nagy Laszlo
Nagy Takacsi
Papp Szikla Z.
Criares T. J.
Henley III Raymond J.
Richter Gedeon Vegyeszeti Gyar Rt.
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