Stable oral preparation of macrolide antibiotics and method for

Details Stable oral preparation of macrolide antibiotics and method for Stable oral preparation of macrolide antibiotics and method for

1986-08-25

1987-12-29

Brown, J. R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514557, 514561, 424115, 424154, 424155, 424156, 424157, A61K 3170, A61K 3119, A61K 3744, A61K 3500

Patent

active

047161531

ABSTRACT:
Stable oral preparations of 16-membered ring macrolide antibiotics such as SF-837, josamycin, 3"-propionyljosamycin, by incorporating stabilizers showing pH 3-10 in an aqueous medium, such as glycine, and dissolution accelerators showing pH 2.5-4 in an aqueous medium such as citric acid or tartaric acid. Coating such dissolution accelerators with a film-forming substance is useful to enhance the stability of the oral preparation of such antibiotics.

REFERENCES:
patent: 3891752 (1975-06-01), Gorton et al.
patent: 3962419 (1976-06-01), Mayama et al.
patent: 4064230 (1977-12-01), Gordon et al.
patent: 4102999 (1978-07-01), Umezowa et al.
patent: 4127647 (1978-11-01), Sato et al.
patent: 4137307 (1979-01-01), Funakoshi et al.
patent: 4327086 (1982-04-01), Fukushima et al.
patent: 4338335 (1982-07-01), McAleer et al.
Merck Index, 9th Ed., No. 2307, 1976.
Chem Pharm Bull. 16, 1402, 1968.
J. Antibiot. 29, 536, 1976.
Chem. Pharm. Bull. 1099, 1962.
Journal of Antibiotics, 28:401 (1975) Chemical & Biol. Studies on 16 Membered Macrolide Antibiotics.
French Search Report.

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