Stable oral CI-981 formulation and process for preparing same

Details Stable oral CI-981 formulation and process for preparing same Stable oral CI-981 formulation and process for preparing same

1997-07-02

2000-10-03

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

514970, A61K 4702

Patent

active

061269719

ABSTRACT:
An oral pharmaceutical composition is provided for treating hypercholestereolemia or hyperlipidemia containing an advantageous formulation for stabilizing the HMG-CoA coenzyme A inhibitor, CI-981 Hemi-Calcium, of formula (IA) ##STR1## with effective amounts of calcium carbonate. A method for preparing a CI-981 stabilizing composition is described.

REFERENCES:
patent: 4681893 (1987-07-01), Roth et al.
patent: 5030447 (1991-07-01), Joshi et al.
patent: 5686104 (1997-11-01), Mills et al.

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