Stable oil-in-water emulsions incorporating a taxine (taxol) and

Details Stable oil-in-water emulsions incorporating a taxine (taxol) and Stable oil-in-water emulsions incorporating a taxine (taxol) and

1994-07-19

1997-04-01

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

252312, 252314, 514511, 514908, 514938, A61K 9107, A61K 31235, B01J 1300

Patent

active

056163304

ABSTRACT:
This invention is directed to a composition of a taxine in a stable oil-in-water emulsion for intravenous administration. The invention also relates to a method for incorporating a taxine into an oil and making a stable oil-in-water emulsion.
The composition includes a taxine, an oil, water and a surfactant. In a preferred embodiment, the taxine is taxol, the oil is safflower oil and the surfactant is lecithin, The taxine is incorporated into the oil by dissolving the taxine in a solution of an oil and a taxine co-solvent, such as isopropanol, for example. The co-solvent then is removed to form a solution of the taxine in oil. This solution may be dispersed in water with a surfactant to form a stable oil-in-water emulsion for intravenous administration.

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