Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrate esters or chalcogen analogues thereof
Reexamination Certificate
2006-03-14
2010-06-29
Wilson, James O (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrate esters or chalcogen analogues thereof
Reexamination Certificate
active
07745656
ABSTRACT:
Disclosed are novel NO-releasing compounds which comprise a stabilized S-nitrosyl group and a free alcohol or a free thiol group. Also disclosed is a method of preparing the NO-releasing compounds. The method comprises reacting a polythiol or a thioalcohol with a nitrosylating agent. Also disclosed are medical devices coated with the disclosed compounds, methods of delivering NO to treatments sites in a subject by utilizing the medical devices and methods of sterilizing surfaces.
REFERENCES:
patent: 5574068 (1996-11-01), Stamler et al.
patent: 5648393 (1997-07-01), Stamler et al.
patent: 5650447 (1997-07-01), Keefer et al.
patent: 5770645 (1998-06-01), Stamler et al.
patent: 6207855 (2001-03-01), Toone et al.
patent: 6359167 (2002-03-01), Toone et al.
patent: 6488951 (2002-12-01), Toone et al.
patent: 6583311 (2003-06-01), Toone et al.
patent: 7015347 (2006-03-01), Toone et al.
patent: 2262922 (1998-02-01), None
patent: 0 412 699 (1991-02-01), None
patent: WO 89/12627 (1989-12-01), None
patent: WO 92/17445 (1992-10-01), None
patent: WO 92/18002 (1992-10-01), None
patent: WO 95/07691 (1995-03-01), None
patent: WO 96/02241 (1996-02-01), None
patent: WO 96/03139 (1996-02-01), None
patent: WO 96/32954 (1996-10-01), None
patent: WO 98/05689 (1998-02-01), None
Askew, S.C., et al., “Catalysis by Cu2+of nitric oxide release fromS-nitrosothiols (RSNO),”J. Chem. Soc. Perkin Trans. 2:741-745 (1995).
Batsanov, A.S., et al., “Stereocontrol in cyclisation of dioxolanyl radicals,”J.Chem Soc. Perkin Trans. 1:1281-1294 (1995).
Goldstein, S. and Czapski, G., “Mechanism of the Nitrosation of Thiols and Amines by Oxygenated NO Solutions: the Nature of the Nitrosating Intermediates,”J. Am. Chem. Soc. 118:3419-3425 (1996).
Gorren, A.C.F., et al., “Decomposition ofS-Nitrosoglutathione in the Presence of Copper Ions and Glutathione,”Arch. of Biochem. and Biophys. 330(2):219-228 (1996).
Roy, B., et al., “New Thionitrites: Synthesis, Stability, and Nitric Oxide Generation,”J. Org. Chem. 59:7019-7026 (1994).
Vanin, A.F., et al., “Iron Catalyzes both Decomposition and Synthesis ofS-Nitrosothiols: Optical and Electron Paramagnetic Resonance Studies,”Nitric Oxide: Biol. and Chem., 1(3):191-203 (1997).
Barrett, J., et al., “Photochemistry of theS-Nitroso Derivatives of Hexane-1-thiol and Hexane-1,6-dithiol,”Nature211:848 (1966).
Bauer, J.A., et al., “Chemical Stabilization of a VasoactiveS-Nitrosothiol with Cyclodextrins Without Loss of Pharmacologic Activity,”Pharmaceutical Research8(10):1329-1333 (1991).
Dicks, A.P., et al., “The reaction ofS-nitrosothiols with thiols at high thiol concentrations,”Can. J. Chem. 76:789-794 (1998).
Le, M., et al., “The Decomposition ofS-Nitrosated Dithiols: A Model for Vicinal Nitrosothiols in Enzymes,”Bioorganic&Medicinal Chemistry Letters7(11):1393-1398 (1997).
Askew, S.C., et al., “Catalysis by Cu2+of nitric oxide release from S-nitrosothiols (RSNO),”J.Chem. Soc. Perkin Trans. 2:741-745 (1995).
Batsanov, A.S., et al., “Stereocontrol in cyclisation of dioxolanyl radicals,”J. Chem Soc. Perkin Trans. 1:1281-1294 (1995).
Goldstein, S. and Czapski, G., “Mechanism of the Nitrosation of Thiols and Amines by Oxygenated •NO Solutions: the Nature of the Nitrosating Intermediates,”J. Am. Chem. Soc. 118:3419-3425 (1996).
Gorren, A.C.F., et al., “Decomposition of S-Nitrosoglutathione in the Presence of Copper Ions and Glutathione,”Arch. of Biochem. and Biophys. 330(2):219-228 (1996).
Roy, B., et al., “New Thionitrites: Synthesis, Stability, and Nitric Oxide Generation,”J. Org. Chem. 59:7019-7026 (1994).
Vanin, A.F., et al., “Iron Catalyzes both Decomposition and Synthesis of S-Nitrosothiols: Optical and Electron Paramagnetic Resonance Studies,”Nitric Oxide: Biol. and Chem., 1(3):191-203 (1997).
Barrett, J., et al., “Photochemistry of the S-Nitroso Derivatives of Hexane-1-thiol and Hexane-1,6-dithiol,”Nature211:848 (1966).
Bauer, J.A., et al., “Chemical Stabilization of a Vasoactive S-Nitrosothiol with Cyclodextrins Without Loss of Pharmacologic Activity,”Pharmaceutical Research8(10):1329-1333 (1991).
Dicks, A.P., et al., “The reaction of S-nitrosothiols with thiols at high thiol concentrations,”Can. J. Chem. 76:789-794 (1998).
Le, M., et al., “The Decomposition of S-Nitrosated Dithiols: A Model for Vicinal Nitrosothiols in Enzymes,”Bioorganic & Medicinal Chemistry Letters7(11):1393-1398 (1997).
International Search Report from counterpart International Application No. PCT/US99/13963, dated Nov. 2, 1999.
Written Opinion of the International Searching Authority from counterpart International Application No. PCT/US99/13963, dated Mar. 17, 2009.
International Preliminary Report on Patentability from counterpart International Application No. PCT/US99/13963, dated Aug. 17, 2000.
Notification of Grounds for Rejection for Japanese Patent Application No. 2000-555864, dated Jun. 29, 2009.
Communication from EPO of Office Action for EP Application No. 99928821.0-2103, dated Sep. 19, 2002.
Communication from EPO of Office Action for EP Application No. 99928821.0-2103, dated May 21, 2004.
Communication from EPO of Office Action for EP Application No. 99928821.0-2103, dated Apr. 8, 2005.
Communication from EPO of Office Action for EP Application No. 99928821.0-2103, dated Jun. 14, 2006.
Communication from EPO of Office Action for EP Application No. 99928821.0-2103, dated Jun. 28, 2007.
Communication from Epo of Office Action for Ep Application No. 99928821.0/2103, dated Jul. 16, 2009.
Communication from EPO of Summons to Attend Oral Proceedings Pursuant to Rule 115(1) EPC for EP Application No. 99928821.0-2103, dated Feb. 2, 2009.
Communication from EPO of Brief Communication Oral Proceedings on Jun. 25, 2009 for EP Application No. 99928821.0-2103, dated Jun. 24, 2009.
Communication from Canadian Intellectual Property Office of an Examiner's Requisition for Canadian Application No. 2,335,989, dated Mar. 2, 2007.
Communication from Canadian Intellectual Property Office of an Examiner's Requisition for Canadian Application No. 2,335,989, dated Nov. 29, 2007.
Communication from Canadian Intellectual Property Office of an Examiner's Requisition for Canadian Application No. 2,335,989, dated Oct. 3, 2008.
Stamler Jonathan S.
Toone Eric J.
Duke University
Hamilton Brook Smith & Reynolds P.C.
Sackey Ebenezer
Wilson James O
LandOfFree
Stable no-delivering compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Stable no-delivering compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stable no-delivering compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4248488