Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent
Patent
1998-02-10
2000-10-24
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Ultrasound contrast agent
600431, 424 951, A61B 5055
Patent
active
06136293&
ABSTRACT:
Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
REFERENCES:
patent: 4224179 (1980-09-01), Schneider
patent: 4229360 (1980-10-01), Schneider et al.
patent: 4256251 (1981-03-01), Moshofsky
patent: 4276885 (1981-07-01), Tickner et al.
patent: 4316391 (1982-02-01), Tickner
patent: 4442843 (1984-04-01), Rasor et al.
patent: 4466442 (1984-08-01), Hilmann et al.
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4572203 (1986-02-01), Feinstein
patent: 4657756 (1987-04-01), Rasor et al.
patent: 4681119 (1987-07-01), Rasor et al.
patent: 4684479 (1987-08-01), D'Arrigo
patent: 4718433 (1988-01-01), Feinstein
patent: 4774958 (1988-10-01), Feinstein
patent: 4832941 (1989-05-01), Berwing et al.
patent: 4844882 (1989-07-01), Widder et al.
patent: 4859363 (1989-08-01), Davis et al.
patent: 4900540 (1990-02-01), Ryan et al.
patent: 4957656 (1990-09-01), Cerny et al.
patent: 5088499 (1992-02-01), Unger
patent: 5123414 (1992-06-01), Unger
patent: 5137928 (1992-08-01), Erbel et al.
patent: 5141738 (1992-08-01), Rasor et al.
patent: 5147631 (1992-09-01), Glajch et al.
patent: 5425366 (1995-06-01), Reinhardt et al.
patent: 5501863 (1996-03-01), Rossling et al.
patent: 5556610 (1996-09-01), Yan et. al.
patent: 5599523 (1997-02-01), Beller et al.
patent: 5711933 (1998-01-01), Bichon et al.
deJong et al Ultrasonics 1992 vol. 30 No. 2 pp. 95-103 Absorption and scatter of encapsulated gas etc.
deJong et al Ultrasonics 1991 vol. 29 Jul. pp. 324-330 Principles and recent developments in ultrasound.
Bleeker et al 1990 J. Ultrasound Med 9:461-471, 1999 pp. 462-471 On the Application of Ultrsonic Contr.
Feinstein et al JACC vol. 16, No. 2 8/90:316-24 Safety and Efficacy of a New Transpulmonary Ultrasou. Amer Hearts Assn Monograph Circulation Part II vol. 72 No. 4 Oct. 1985 Abstracts of the 58.sup.th Scientific Ses.
Amer Hearts Assn Monograph Circulation Part II vol. 72 No. 4 Oct. 1985 Abstracts of the 58.sup.th Scientific Ses.
Bleeker et al J. Acoust. Soc. Am. 87 (4) Apr. 1990 pp. 1792-1797 Ultrasonic characterization of Albunex.RTM. etc.
Epstein et al J. Chem. Physics vol. 18, No. 11, Nov. 1950 On the Stability of Gas Bubbles in Liquid-Gas Solu.
Meltzer et al Ultrasound in Med & Biol vol. 7, No. 4 pp. 377-384 1981 Transmission of Ultrasonic Contra.
Violante et al Investigative Radiology vol. 26 Nov. Supp 1991 Particle-Stabilized Bubbles for Enhanced.
Ohta et al Jpn J Med Ultrasonics vol. 18 No. 4 (1991) Effect of the Contrast Agent and the Agitation Met.
Feinstein et al Am J of Physiologic Imaging 1:12-18 (1986) Myocardial Contrast Echocardiography etc.
Widder et al AJR:147, Aug. 1986 Microbubbles as Contrast Agent for Neurosonography and Ultrasound-et.
Schlief Current Opinion in Radiology 1993, 3:198-207 ultraqsound Contrast Agents.
Fobbe et al Furtschr Rontgenstr 154.3 (1991)242-245 Farbkodierte Duplexsonographic und Ultra-etc.
Ophir et al Ultrasound in Med & Biol vol. 15 No. 4 pp. 319-333 1989 Contrast Agents in Diagnostic Ultras.
Swanson, pp. 682-687 "Chapter 22: Enchancement Agents for Ultrasound: Fundamentals" in Pharmaceuticals in Medical Imaging, (EDS. Swanson et al., MacMillan Publishing Company, New York, 1990).
Lincoff et al Intravitreal Longevity of Three Perfluoorcarbon Gases, Arch. Ophthalmology, 98: 1610-1611 (1980).
Lincoff et al Intravitreal Expansion of Pefluorrocarbon Bubbles, Arch. Ophthalmology, 98:1646 (1980).
Lincoff et al The Perfluorocarbon Gases in the Treatment of Retinal Detachment, Ophthalmoloy, 90(5):546-551 (1983).
Lincoff et al Perfluoro-n-butane: A Gas for Maximum Duration Retinal Tamponade, Arch Ophthalmology, 101:460-463(1983).
Gardner et al (1988) "A Survey of Intraocular Gas Use in North America," Arch Ophthalmol. 106:1188-1189.
Barrau Marie-Bernadette
Bichon Daniel
Bussat Philippe
Grenier, deceased Pascal
Hybl Eva
Bracco International B.V.
Hollinden Gary E.
LandOfFree
Stable microbubbles suspensions containing saturated lamellar ph does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Stable microbubbles suspensions containing saturated lamellar ph, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stable microbubbles suspensions containing saturated lamellar ph will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1960511