Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent
Patent
1993-10-12
1995-08-29
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Ultrasound contrast agent
424450, 424 952, A61K 4900
Patent
active
054458137
ABSTRACT:
Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.
REFERENCES:
patent: 4684479 (1987-08-01), D'Arrigo
patent: 4957656 (1990-09-01), Cerny et al.
patent: 5271928 (1993-12-01), Schneider et al.
Brochot Jean
Puginier Jerome
Schneider Michel
Yan Feng
Bracco International B.V.
Cebulak Mary C.
Hollinden Gary E.
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