Stable microbubble suspensions as enhancement agents for ultraso

Details Stable microbubble suspensions as enhancement agents for ultraso Stable microbubble suspensions as enhancement agents for ultraso

1995-03-31

1997-01-28

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Ultrasound contrast agent

424 952, 424450, 12866202, 514 78, 514121, A61B 808

Patent

active

055975496

ABSTRACT:
Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.

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patent: 5195520 (1993-05-01), Schlief et al.
patent: 5271928 (1993-12-01), Schneider et al.
patent: 5352436 (1994-10-01), Wheatley et al.

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