Stable medicated animal care formulation

Details Stable medicated animal care formulation Stable medicated animal care formulation

2001-09-06

2003-01-14

Pryor, Alton (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Biocides; animal or insect repellents or attractants

C424S406000, C514S066000, C514S531000, C514S572000, C514S937000, C514S941000, C514S943000

Reexamination Certificate

active

06506396

ABSTRACT:

BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to animal care formulations, and, more particularly, to a stable medicated shampoo formulation for treating animals to control parasites thereon.
2. Description of the Prior Art
K. Narayanan, in U.S. Pat. No. 6,045,816, described a water-based microemulsion of an active pyrethroid insecticide for delivery of the active at a high loading to treat fruits and vegetables. The disclosure in this patent is hereby incorporated by reference herein. In this invention, there is provided a stable medicated shampoo formulation including the Narayanan microemulsion matrix, or a modified matrix thereof, for controlling parasites on animals.
SUMMARY OF THE INVENTION
What is described herein is a stable medicated animal care formulation which includes, by weight;
(a) 0.1-10% of an active agricultural ingredient, of an animal care and/or veterinary reagents,
(b) 0.0002-40% of a microemulsion concentrate including
(i) 0-10% of a castor oil ethoxylate or tristyrl phenol ethoxylate,
(ii) 0-1% of an ethoxylated phosphoric acid as pH buffer,
(iii) 0.0002-4% of a N—C
8
-C
8
-C
18
alkyl pyrrolidone and
(iv) 0-6% of a N—C
1
-C
4
alkyl pyrrolidone,
(c) a surfactant with shampoo properties, and
(d) water.
In a preferred form of the invention, (a) is an insecticide, most preferably, permethrin, deltamethrin, D-allethrin, piperonyl butoxide, bioresmethrin, penconozole, a mixture of D-allethrin/piperonyl butoxide, or a mixture of D-allethrin/permethrin/ tetramethrinlipiperonyl butoxide.
Preferably, too, the total amount of (c) and (d) in the formulation is 50-99.4%, and (b) (iii) is N-octyl or N-dodecyl pyrrolidone and (b) (iv) is N-methyl pyrrolidone.
DETAILED DESCRIPTION OF THE INVENTION
In this invention, the microemulsion matrix in Narayanan, referred to hereinafter as MICROFLEX-1, or a modified form thereof, is present in a medicated shampoo formulation containing an active agricultural ingredient, such as an insecticide, e.g. a pyrethroid, for treating an animal suspected of having a parasite thereon.
The formulation, by weight is as follows:
(a) active agricultural ingredient, 0.1-10%;
(b) MICROFLEX-1, 0.00002-40%;
(i) castor oil ethoxylate or tristyryl phenol, 0-10%,
(ii) ethoxylate phosphoric acid, 0-1%,
(iii) N—C
8
-C
18
alkyl pyrrolidone 0.0002-4%, and
(iv) N—C
1
-C
4
alkyl pyrrolidone 0-6%.
(c) surfactant with shampoo properties, e.g. anionic surfactant;
(d) water, wherein (c)+(d), 50-99.4%.
Preferably, both (b) (ii) and (iv) are present, (b) (iii) is octyl pyrrolidone or dodecyl pyrrolidone, and (b) (iv) is methyl pyrrolidone. In the modified MICROFLEX-1 matrix, essentially only (b) (iii) is present and it is preferably N-dodecyl pyrrolidone.
Generally, the agriculturally active ingredient used herein is an insecticide, preferably a pyrethroid, which is a class of well-known and widely-used insecticide of which cypermethrin, o-allethrin, permethrin, piperonyl butoxide and tetramethrin are representative examples.
The shampoo portion of the formulation includes a surfactant having shampoo properties. A typical formulation is as follows, in weight %.
Shampoo Formulation A
Weight %
Sodium Laureth 2 sulfate
9.20
Cocamidopropyl-betaine
5.10
Cocamide DEA
4.05
Deionized Water
81.45 
Citric Acid (25%)
0.20
Total
100.00 
Procedure
Dissolve sodium laureth sulfate in water
Heat the solution to 65° C.
Add Cocamidopropylbetain and Cocamide DEA
Stir the mixture until the solution is homogeneous
Cool to 45° C.
Add citric acid solution to the mixture and stir
Cool to room temperature
A clear, viscous liquid is formed.
[Shampoo Viscosity (LUT/4 sp 12 rpm/min) 7500 cps]


REFERENCES:
patent: 6045816 (2000-04-01), Narayanan et al.

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