Stable liquid form of 5-aminosalicylic acid

Details Stable liquid form of 5-aminosalicylic acid Stable liquid form of 5-aminosalicylic acid

1989-05-15

1991-04-23

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514474, 514973, A61K 31615, A61K 3134

Patent

active

050100696

ABSTRACT:
An aqueous solution of 5-aminosalicylic acid (5-ASA) and a nontoxic alkali, alkali metal or alkaline earth metal salt of 5-aminosalicylic acid having a pH of 3-5 is disclosed. The sole buffer in the solution is that intrinsically formed by 5-aminosalicylic acid and its alkali, alkali metal or alkaline earth metal salt. The solutions preferably also contain an antioxidant and a metal complexing agent. In preferrred practice, the 5-ASA salt is formed in situ by addition of an alkali, alkali metal or alkaline earth metal hydroxide to a solution of 5-ASA. The solution is stable and does not significantly discolor due to 5-ASA decomposition for extended periods of time.

REFERENCES:
patent: 2647853 (1953-08-01), Larde et al.
patent: 4657900 (1987-04-01), Powell et al.
patent: 4664256 (1987-05-01), Halskov

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