Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1992-12-29
1995-01-24
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
514492, 556137, A61K 3722, A61K 3128, C07F 1500
Patent
active
053841271
ABSTRACT:
Lipophilic complexes having the structure
REFERENCES:
patent: 3904663 (1975-09-01), Tobe et al.
patent: 3993754 (1976-11-01), Rahman et al.
patent: 4115418 (1978-10-01), Gale et al.
patent: 4137248 (1979-01-01), Gale et al.
patent: 4140707 (1979-02-01), Cleare et al.
patent: 4169846 (1979-10-01), Kidani et al.
patent: 4203912 (1980-05-01), Hydes et al.
patent: 4225529 (1980-09-01), Hydes et al.
patent: 4230631 (1980-10-01), Hydes et al.
patent: 4235871 (1980-11-01), Papahadjoponlous
patent: 4241046 (1980-12-01), Papahadjoponlous
patent: 4256652 (1981-03-01), Kidani et al.
patent: 4271085 (1981-06-01), Amundsen et al.
patent: 4284579 (1981-08-01), Meischen et al.
patent: 4330534 (1982-05-01), Sakurai et al.
patent: 4431666 (1984-02-01), Bulten et al.
patent: 4466924 (1984-08-01), Verbeek et al.
patent: 4522803 (1985-06-01), Lenk et al.
patent: 4657927 (1987-04-01), Cleare et al.
patent: 4661516 (1987-04-01), Brown et al.
patent: 4663167 (1987-05-01), Lopez-Berestein
patent: 4680308 (1987-07-01), Schwartz et al.
patent: 4760155 (1988-07-01), Heffernan et al.
patent: 4760156 (1988-07-01), Heffernan et al.
patent: 4760157 (1988-07-01), Child et al.
patent: 4946954 (1990-08-01), Talebian et al.
patent: 4956459 (1990-08-01), Talebian et al.
patent: 5041581 (1991-08-01), Khokhar et al.
patent: 5117022 (1992-05-01), Khokhar et al.
patent: 5178876 (1993-01-01), Khokhar et al.
Chemical Abstract, "Cis-1,2-Diaminocyclohexane Platinum Complexes", 101:177510w (1984).
Maeda, Japan Journal Cancer Research (Gann), "Liposoluble Platinum(II) Complexes with Antitumor Activity", 77:523-525 (Jun. 1986).
Kihara, Chemical Abstracts, "Organoplatinum Complexes as Antineoplastics", 105:134160x (1986).
Craciunescu, et al., "On the Preparation, Antitumour and Cytotoxic Evaluation of Some New Analogues of the Cis-Dichloro(1,2-Diamino-Cyclohexane) Platinum(II) Complex", Eur. J. Med. Chem., 19:353-357 (1984).
Sur, et al., "Effect of Liposomal Encapsulation of Cis-Platinum Diamminodichloride in the Treatment of Ehrlich Ascites Carcinoma", Oncology, 40:372-376 (1983).
Freise, et al., "Pharmacokinetics of Liposome Encapsulated Cisplatin in Rats", Archives Internationales de Pharmacodynamie et de Therapie, 258:180-192 (Aug. 1982).
Kaledin, et al., "Intralymphatic Administration of Liposome-Encapsulated Drugs to Mice: Possibility for Suppression of the Growth of Tumor Metastases in the Lymph Nodes", JNCI, 66:881-886 (May 1981).
Deliconstantinos, et al., "Dichlorobiscyclopentylamineplatinum(II) into Liposomes Enhances its Uptake by ADJ/PC6A Tumors Implanted Subcutaneously Into Mice", Biochem. Soc. Trans., 5:1326-1328 (1977).
Yatvin, et al., "Selective Delivery by Hyperthermia of Liposome Encapsulated Cis Dichlorodiamine Platinum(II) and Tumor Growth Delay (Meeting Abstract)", Proc. Am. Assoc. Cancer Res., 21:281 (1980).
Szoka, Jr., and Papahadjopoulos, "Comparative Properties and Methods of Preparation of Lipid Vesicles (Liposomes)", Ann. Rev. Biophys. Bioeng., 9:467-508 (1980).
Swartz, "Preparation and Antitumor Evaluation of Water-Soluble Derivates of Dichloro(1,2-Diaminocyclohexane)Platinum(II)", Chemical Abstracts, 88:16014k (1978).
Swartz et al., "Preparation and Antitumor Evaluation of Water-Soluble Derivatives of Dichloro(1,2-Diaminocyclohexane)Platinum(II).sup.1,2 ", Cancer Treatment Reports, 61:1519-1525 (Nov. 1977).
Perez-Soler, "Toxicity and Antitumor Activity of cis-Bis-cyclopentenecarboxylato-1,2-diaminocyclohexane Platinum(II) Encapsulated in Multi-lamellar Vesicles", Cancer Research 46, 6269-6273 (1986).
Connors, "New Platinum Complexes with Anti-Tumor Activity", Chem. Biol. Interactions, 5:415-424 (1972).
Ridgway et al., "Analogs of Sulfato 1,2-Diaminocyclohexane Platinum(II). I. Modifications in Leaving Ligand", J. Clin. Hematol. Oncol. 7:220-229 (1977).
Burchenal, "Rationale of Combination Chemotherapy", Chemical Abstracts 93:125661t (1980).
Appleton, "Reactions of Platinum(II) Aqua Complexes", Chemical Abstracts 101:182656c (1984).
Speer, "Malonato-1,2-Diaminocyclohexaneplatinum(II) , A Potential Antitumor Agent", Chemical Abstracts 84:5403n (1976).
Khokhar, "The Synthesis and Antitumor Properties of a Series of Water Soluble Carboxylato(1,2-diaminocyclohexane)platinum(II) Complexes", Chemical Abstracts 103:226308p (1980).
Tzu, "Synthesis and Study of Some Platinum Complexes with Dicarboxylic Acids", Chemical Abstracts 94:218774t (1981).
Khokhar et al., "The Synthesis and Antitumor Properties of a Series of Water Soluble Carboxylato-(1,2-Diaminocyclohexane)Platinum(II) Complexes", Inorganica Chimica Acta, 108:63-66 (1985).
Perez-Soler et al., "Phase I Clinical and Pharmacological Study of Liposome-entrapped cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane Platinum(II)", Cancer Research, 50:4254-4259 (Jul. 15, 1990).
Khokhar et al., "Toxicity and Antitumor Activity of cis-bis-carboxylato-(trans-R,R-1,2-diaminocyclohexane) Platinum(II) Complexes Entrapped in Liposomes", Cancer, Chemotherapy and Pharmacology, 23(4):219-224 (1989).
Han Insook
Khokhar Abdul R.
Perez-Soler Roman
Board of Regents , The University of Texas System
Dees Jos,e G.
Nazario Porfirio
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