Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Reexamination Certificate
2006-04-28
2009-10-27
Anderson, Rebecca L (Department: 1626)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
C435S106000, C435S131000, C530S350000
Reexamination Certificate
active
07608248
ABSTRACT:
The present invention herein provides, for instance, a stable isotope-labeled phenylalanine wherein a carbon atom of the phenyl group linked to an amino acid residue is13C, 2 to 4 carbon atoms of the remaining 5 carbon atoms constituting the phenyl group are12C atoms to which deuterium atoms are bonded, and the remaining carbon atoms are13C atoms to which hydrogen atoms are linked, and a stable isotope-labeled tyrosine wherein a carbon atom of the phenyl group linked to an amino acid residue is13C, the carbon atom bonded to the hydroxyl group (OH group) of the phenyl group is12C or13C, 2 to 4 carbon atoms of the remaining 4 carbon atoms constituting the phenyl group are12C atoms to which deuterium atoms are bonded, and the remaining carbon atoms are13C atoms to which hydrogen atoms are linked. The stable isotope-labeled amino acid permits the elimination of such a conventional problem concerning the complexity of the NMR signals ascribed to aromatic rings, the complexity being a principal cause of making the NMR analysis difficult, encountered when using the conventional uniformly labeled amino acid residue. Moreover, the isotope-labeled amino acid likewise permits the substantial improvement of the sensitivity thereof to the NMR spectroscopic analysis.
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Kainosho Masatsune
Terauchi Tsutomu
Anderson Rebecca L
Hoffmann & Baron , LLP
Japan Science and Technology Agency
Young Shawquia
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