Stable intravenously-administrable immune globulin preparation

Details Stable intravenously-administrable immune globulin preparation Stable intravenously-administrable immune globulin preparation

1997-09-22

1999-08-31

Sayala, Chhaya D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

514 2, 514 12, 514 21, 5303871, 5303891, 530380, 5303905, A61K 3821

Patent

active

059450983

ABSTRACT:
Stable, intravenously-administrable immune globulin preparations are stabilized against aggregation and polymerization and rendered isotonic with amino acid(s) and non-ionic detergents, polysorbate and polyethylene glycol. The immunoglobulins are derived from human or animal sources, or from hybridomas. Optional, additional stabilizers include various physiologically-acceptable carbohydrates and salts. Polyvinylpyrrolidone can be used in addition to the amino acid(s). Apart from the immunoglobulin itself, the preparations are otherwise essentially protein free. The preparations are useful in immunotherapy and as diagnostic reagents.

REFERENCES:
patent: 3903262 (1975-09-01), Pappenhagen et al.
patent: 4165370 (1979-08-01), Coval
patent: 4168303 (1979-09-01), Nishida et al.
patent: 4186192 (1980-01-01), Lundblad et al.
patent: 4362661 (1982-12-01), Ono et al.
patent: 4371520 (1983-02-01), Uemura et al.
patent: 4374763 (1983-02-01), Takagi
patent: 4384993 (1983-05-01), Sato et al.
patent: 4396608 (1983-08-01), Tenold
patent: 4439421 (1984-03-01), Hooper et al.
patent: 4477432 (1984-10-01), Hardie
patent: 4482483 (1984-11-01), Curry et al.
patent: 4540573 (1985-09-01), Neurath et al.
patent: 4565651 (1986-01-01), Ohmura et al.
patent: 4597966 (1986-07-01), Zolton et al.
patent: 4613501 (1986-09-01), Horowitz
patent: 4623717 (1986-11-01), Fernandes et al.
patent: 4637834 (1987-01-01), Thurow
patent: 4639513 (1987-01-01), Hou et al.
patent: 4692331 (1987-09-01), Uemura et al.
patent: 4719290 (1988-01-01), Curry et al.
patent: 4721777 (1988-01-01), Uemura et al.
patent: 4764369 (1988-08-01), Neurath et al.
patent: 4789545 (1988-12-01), Woods et al.
patent: 4876088 (1989-10-01), Hirao et al.
patent: 4877608 (1989-10-01), Lee et al.
patent: 5177194 (1993-01-01), Saras et al.
Tomono et al., Vox Sang vol. 51 (2) pp. 81-86 (1986).
Stephan, W., "Undegraded Gamma-Globulin for Intravenous Therapy: A New Preparation of Immune Serum Globulin for Intravenous Administration," XXIVth Scientific Meeting of the Blood Research Institute, pp. 469-478, 1971.
Fernandes et al., "Preparation of a Stable Intravenous Gamma-Globulin: Process Design and Scale-Up," Vox Sang. 39: 101-12 (1980).
Gerber, "Stabilization of Gamma Globulin with Copper Complexes: Possible Relevance to the Etiology of Rheumatoid Arthritis," Inflammation Diseases and Copper (1982).
Gerber, "Inhibition of Denaturation of Human Gamma Globulin by a Mixture of L-Histidine, L-Cystine, and Copper, and Its Clinical Implication in Rheumatoid Arthritis," Arthritis and Rheumatism, vol. 19, 3:593-601 (1976).
Florence et al., "Emulsion Stabilization by Non-Ionic Surfactants: Experiment and Theory," J. Pharm. Pharmac. 23:153-169 (1971).
Miller, G., et al., "Stabilization of Cytotoxic Antibody and Complement with Cysteine," J. of Immun., vol. 101, No. 5, pp. 1074-1077 (1968).

Affiliated with

Also associated with

Rating

Stable intravenously-administrable immune globulin preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stable intravenously-administrable immune globulin preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stable intravenously-administrable immune globulin preparation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2425919