Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-06-11
2000-03-07
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530304, A61K 3828
Patent
active
060340541
ABSTRACT:
The present invention provides a monomeric insulin analog formulation stabilized against aggregation in which the buffering agent is either TRIS or arginine. The stable formulations of the present invention are useful for treating diabetes, and are particularly advantageous in treatment regimes requiring lengthy chemical and physical stability, such as, in continuous infusion systems.
REFERENCES:
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Patent Abstract of Japan, vol. 006, No. 143, C-117, Aug. 3, 1982 & JP 57 067548 A (Shionogi & Co Ltd), Apr. 24, 1982, refers to preparation comprising insulin analogues in the prescence of glycerine, trishydroxy-methylaminomethane, ZnCl2 and cresol-phenol as an antiseptic.
J. Brange, et al., "Chemical stability of insulin", Aeta Pharm. Nord. 4(3) 149-158 (1992).
R. Quinn, et al., "Minimizing the aggregation of neutral insulin solutions", Journal of Pharmaceutical Sciences vol. 72, No. 12, Dec. 1983.
Brems, et al. Protein Engineering, 6:527-533 (1992).
Brange, et al., Current Opinion in Structural Biology, 1:934-940 (1991).
DeFelippis Michael Rosario
Dobbins Michael Allen
Frank Bruce Hill
Li Shun
Rebhun Dawn Marie
Eli Lilly and Company
Russel Jeffrey E.
Stewart Mark J.
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