Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-05-01
1992-12-22
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514973, 544258, A61K 31505, A61K 4710, A61K 4720, A61K 4718
Patent
active
051734885
ABSTRACT:
Injectable aqueous compositions comprising folic acid and leucovorin and their salts, optionally including benzyl alcohol, sodium chloride and agents for adjusting pH are stabilized and buffered in the range of 6 to 10 by adding a combination of tromethamine and monothioglycerol. Such compositions remain stable for prolonged periods even when exposed to sunlight.
REFERENCES:
patent: 1926797 (1933-09-01), Sutton
patent: 2688018 (1954-08-01), Cosulich
patent: 2695860 (1954-11-01), Weidenheimer et al.
patent: 2741608 (1956-08-01), Shive
patent: 3696195 (1972-10-01), Crivellaro et al.
patent: 4071620 (1978-01-01), Sklar
patent: 4500711 (1985-02-01), Wisowaty et al.
patent: 4931441 (1990-06-01), Lawrence
Physicians Desk Reference (Oradell, N.J., Medical Economics Co., 1988) pp. 1148-1152.
Durst, et al. Clinical Chemistry 18, (3) 1972, pp. 206-208.
United States Pharmacopeia, XX, 1980, pp. 832-833, and 1237.
American Cyanamid Company
Bond Robert T.
Szatkowski Thomas S.
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