Stable injectable antiemetic compositions

Details Stable injectable antiemetic compositions Stable injectable antiemetic compositions

1987-03-10

1989-11-21

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514970, A61K 31165

Patent

active

048823562

ABSTRACT:
Stable, injectable, aqueous solutions of 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[(substituted)alkoxy]benzamid e antiemetic agents are prepared by adding, as stabilizing agent, a pharmaceutically acceptable, water-miscible, hydroxylic organic solvent or water-soluble polyhydric alcohol or sugar which decreases the polarity of the solution.

REFERENCES:
patent: Re26541 (1969-03-01), Remmers et al.
patent: 4323577 (1982-04-01), Ohkuma et al.
Remington's Pharmaceutical Sciences, 15th Ed. (1975), Mack Pub. Co., Easton, PA, p. 1465.
PDR, 42 Ed. (1988), pp. 1696-1698.
Remington's Pharmaceutical Sciences, 15th Ed. (1975), Mack Publishing Company, Easton, PA, pp. 165 & 166.

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