Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Reexamination Certificate
2002-12-09
2003-10-21
Dodson, Shelley A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
C424S060000, C424S400000, C424S401000
Reexamination Certificate
active
06635239
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Technical Field of the Invention
The present invention relates to novel cosmetic and/or dermatological compositions well suited for the artificial/sunless tanning and/or browning of human skin and comprising, formulated into a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier thereof, at least one specific amino-substituted 2-hydroxybenzophenone compound and at least one self-tanning agent.
The present invention also relates to a cosmetic treatment regime or regimen for artificially tanning or browning the skin and to the concordant administration of at least one specific amino-substituted 2-hydroxybenzophenone compound for improving the coloring capability and/or the stability of a self-tanning agent.
This invention also relates to the topical application of the subject compositions for the coloring/browning of the skin to impart an appearance similar to natural tanning of the skin.
By the term “self-tanning agent” or “artificial/sunless tanning agent” are intended agents which, when topically applied onto the skin, in particular onto the face, elicit a tanning effect with an appearance more or less similar to that resulting from prolonged exposure to the sun (natural tanning) or under a UV lamp.
2. Description of the Prior Art
It is today important to look well and a tanned skin is always a sign of good health. However, natural tanning is not always desirable insofar as it requires prolonged exposure to UV radiation, in particular to UV-A radiation, which causes browning of the skin but, on the other hand, can induce reactions, indeed even a detrimental change, in the skin, in particular in the case of sensitive skin or skin continually exposed to solar radiation: erythema, burns, loss of elasticity, appearance of wrinkles, premature aging. It is therefore desirable to have available an alternative to natural tanning which is compatible with the requirements of such skin.
The majority of cosmetic products for the artificial tanning of the skin are based on carbonyl derivatives which permit the formation of colored compounds by interaction with the amino acids of the skin. These compounds include mono- or polycarbonyl compounds, such as, for example, isatin, alloxan, ninhydrin, glyceraldehyde, mesotartaric aldehyde, glutaraldehyde, erythrulose and dihydroxyacetone (DHA).
DHA is a particularly preferred compound which is commonly formulated into cosmetics as an agent for the artificial or sunless tanning of the skin. Applied onto the skin, in particular onto the face, it elicits a tanning or browning effect having an appearance similar to that resulting from prolonged exposure to the sun (natural tanning) or under a UV lamp.
One disadvantage of DHA is the slow speed at which the coloration develops: this is because several hours (3 to 5 hours in general) are required for the coloration to develop. The intensity of the coloring obtained on the skin and/or its behavior over time (resistance to washing) and/or the speed with which the coloration develops are often regarded as inadequate by users of DHA-based self-tanning compositions.
Another drawback of DHA-based compositions is that they exhibit the unfortunate tendency, more or less pronounced depending on the nature of the medium into which they are formulated, to decompose over time. These disadvantages and drawbacks, related to the storage and/or to the preservation of DHA-based compositions, are generally reflected over prolonged periods of time by an undesirable yellowing of such compositions.
Thus, an increasing demand continues to exist for self-tanning products which act rapidly and impart a coloration similar to natural tanning.
SUMMARY OF THE INVENTION
It has now surprisingly and unexpectedly been determined that formulating certain judiciously selected amino-substituted 2-hydroxybenzophenone compounds into artificial/sunless tanning compositions improves the stability and the extent of coloration of compositions comprising a self-tanning agent. The colorations provided are more chromatic, are more stable over time and have good homogeneity.
The compositions according to the present invention comprise, formulated into a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor, at least one amino-substituted 2-hydroxybenzophenone compound of formula (I) as defined below and at least one self-tanning agent.
The present invention also features administration of the subject compositions for the artificial/sunless tanning or browning of the skin. Also featured is a cosmetic regime or regimen for the tanning or browning of the skin which comprises topically applying onto the skin, an effective amount of a composition according to the invention.
Too, this invention also features formulating at least one amino-substituted 2-hydroxybenzophenone compound of formula (I) as defined below into compositions for the artificial tanning and/or browning of human skin comprising at least one self-tanning agent, for the purpose of improving the coloration capacity and/or the stability of the self-tanning or artificial/sunless tanning agent.
The compositions of the present invention permit obtaining an artificial coloration similar to natural tanning in a short period of time. Thus, an immediate coloring is provided, which is visually quite apparent and which, consequently, enables better homogeneity in the spreading of the composition over the skin and thus of the coloration which results therefrom. Furthermore, the artificial coloring obtained on the skin according to the invention is very similar to natural tanning.
DETAILED DESCRIPTION OF BEST MODE AND SPECIFIC/PREFERRED EMBODIMENTS OF THE INVENTION
More particularly, the amino-substituted 2-hydroxybenzophenone compounds in accordance with this invention have the following structural formula (I):
in which R
1
and R
2
, which may be identical or different, are each a hydrogen atom, a C
1
-C
20
alkyl radical, a C
2
-C
10
alkenyl radical, a C
3
-C
10
cycloalkyl radical or a C
3
-C
10
cycloalkenyl radical, with the proviso that R
1
and R
2
can together form, with the nitrogen atom to which they are bonded, a 5- or 6-membered heterocyclic ring member; R
3
and R
4
, which may be identical or different, are each a C
1
-C
20
alkyl radical, a C
2
-C
10
alkenyl radical, a C
3
-C
10
cycloalkyl radical, a C
3
-C
10
cycloalkenyl radical, a C
1
-C
12
alkoxy radical, a (C
1
-C
20
)alkoxycarbonyl radical, a C
1
-C
12
alkylamino radical, a di(C
1
-C
12
)alkylamino radical, an aryl radical or a heteroaryl radical which is optionally substituted, or a water-solubilizing substituent selected from among a carboxylate group, a sulfonate group or an ammonium residue; X is a hydrogen atom or a —COOR
5
or —CONR
6
R
7
radical; R
5
, R
6
and R
7
, which may be identical or different, are each a hydrogen atom, a C
1
-C
20
alkyl radical, a C
2
-C
10
alkenyl radical, a C
3
-C
10
cycloalkyl radical, a C
3
-C
10
cycloalkenyl radical, a —(YO)
o
—Z radical or an aryl radical; Y is —(CH
2
)
2
—, —(CH
2
)
3
—, —(CH
2
)
4
— or —CH—CH
3
—CH
2
—; Z is —CH
2
—CH
3
, —CH
2
CH
2
CH
3
, —CH
2
—CH
2
—CH
2
—CH
3
or —CH(CH
3
)—CH
3
; m is an integer ranging from 0 to 3; n is an integer ranging from 0 to 3; and o is an integer ranging from 1 to 2.
Representative C
1
-C
20
alkyl radicals include, for example: methyl, ethyl, n-propyl, 1-methylethyl, n-butyl, 1-methylpropyl, 2-methylpropyl, 1,1-dimethyl-ethyl, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methyl-butyl, 2,2-dimethylpropyl, 1-ethylpropyl, n-hexyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl, 1-ethyl-2-methylpropyl, n-heptyl, n-octyl, n-nonyl, n-decyl, n-undecyl, n-dodecyl, n-tridecyl, n-tetradecyl, n-pentadecyl, n-hexadecyl, n-heptadecyl, n-octadecyl, n-nonadecyl or n-icosyl.
Representative
Burns Doane Swecker & Mathis L.L.P.
Dodson Shelley A.
Societe l'Oreal S.A.
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